Many people researching blood sugar supplements already take medication. So I took every ingredient printed on the label and checked it against the published interaction warnings linked below, from the NIH, the FDA and Memorial Sloan Kettering.
Is Sugar Reset Safe To Take With Medication?
For most healthy adults who take no regular medication, the amounts on this label are small. The formula is a mix of common botanicals and amino acids, each sold on its own as a supplement. The label itself asks pregnant or nursing women, anyone under 18 and anyone with a medical condition to check with a doctor first.
If you take medication, seven drug groups deserve a check first. None is an automatic no.
The reassuring part. The manufacturer is not hiding the question: the label already tells people with a medical condition to ask a physician. This article does that homework ingredient by ingredient.
Why Do The Amounts Matter So Much Here?
Most interaction warnings come from studies that used a full dose of one ingredient. Sugar Reset has 22 ingredients sharing a single 200 mg blend. Averaged out, that is about 9 mg each.
Blend ingredients are listed from heaviest to lightest, and the exact split is not disclosed. That is why this article says “check”, not “danger”.
The one disclosed dose makes the point. Chromium is 0.7 mcg per serving. The NIH Office of Dietary Supplements notes that chromium studies for blood sugar have used 200 to 1,000 mcg a day, roughly 300 to 1,400 times more.
Why check anyway: small amounts of several ingredients pushing in the same direction can add up. At least three ingredients here can lower blood sugar. If your medication does too, the effects stack.
Can You Take It With Metformin, Insulin Or Other Diabetes Medication?
This is the most important section, because it is the one most likely to apply to you. At least three ingredients in the blend can lower blood glucose:
- Gymnema leaf. A 2018 risk assessment by Germany’s Federal Institute for Risk Assessment found reports of low blood sugar episodes and medication adjustments when gymnema was combined with diabetes drugs, and concluded that combined use “may be associated with risks when used without medical supervision”.
- Panax ginseng. The NIH’s complementary health center says Asian ginseng might lower blood sugar and that people with diabetes should consult a provider first. Memorial Sloan Kettering lists it as possibly increasing the effect of insulin and sulfonylureas.
- Chromium. Memorial Sloan Kettering lists additive blood sugar lowering with insulin and sulfonylureas. At 0.7 mcg this one is the least likely to matter.
Who should be most careful: people on insulin, or on sulfonylureas such as glipizide, glyburide or glimepiride. These drugs can push blood sugar low on their own. Metformin alone rarely does, so the risk there is lower, but not zero.
Never use a supplement to replace diabetes medication. If your doctor agrees you can try it, check your glucose more often for the first two weeks. Shakiness, sweating, sudden hunger or confusion can mean your blood sugar is too low.
What About Blood Pressure Medication And Diuretics?
Unusually, this label contains ingredients that push blood pressure in opposite directions.
Monoammonium glycyrrhizinate is a licorice compound. The NIH warns that glycyrrhizin can cause irregular heartbeat, especially in large amounts or long-term use, and that even modest amounts have been linked to problems in people with high blood pressure or heart or kidney conditions. Memorial Sloan Kettering adds that licorice may increase the risk of low potassium with diuretics and may work against blood pressure medication.
Coleus forskohlii and L-arginine go the other way. Memorial Sloan Kettering notes that laboratory experiments suggest forskolin may lower blood pressure, with clinical relevance not yet established, and that arginine may have additive effects with them.
If you take a diuretic (a “water pill”), an ACE inhibitor, a beta-blocker or a calcium channel blocker, ask first and check your blood pressure at home for two weeks.
Is It Safe With Heart Rhythm Drugs Like Digoxin Or Amiodarone?
These drugs have a narrow safe range, so this is where we would be most cautious.
- Digoxin: Memorial Sloan Kettering warns licorice may increase its toxicity, mainly through low potassium. It also cites a case report in which Eleuthero, ingredient 5 on this label, raised digoxin levels.
- Amiodarone: the FDA lists it among drugs affected by grapefruit, and guarana changed its absorption in an animal study.
If you take either, ask your cardiologist.
Can You Take It With Warfarin Or Other Blood Thinners?
Ask first. Memorial Sloan Kettering flags two ingredients: guarana and forskolin, both of which may add to bleeding risk. The evidence is mostly from laboratory studies, and the amounts here are small.
Asian ginseng is a mixed picture: studies disagree on whether it weakens warfarin. Because warfarin needs regular blood tests, your prescriber is the right person to decide.
Does The Grapefruit Interact With Statins?
Nobody can say from the label: grapefruit fruit extract is ingredient 11 of 22, with no amount given.
The FDA explains that grapefruit can block an enzyme in the gut, so more of some drugs enters the blood and stays longer. Its list includes some statins, such as simvastatin and atorvastatin, and some blood pressure drugs such as nifedipine.
Green tea is also in the blend. The NIH notes that green tea extract can lower blood levels of atorvastatin, and that high doses reduced the effect of the beta-blocker nadolol. A trace amount in a 200 mg blend is far from that, but it is one more reason to mention the label.
What About Thyroid Medication?
This one is easy to solve. Memorial Sloan Kettering reports that chromium picolinate reduced the absorption of levothyroxine and recommends waiting several hours between the two.
At 0.7 mcg the effect is probably negligible, and the fix is free: thyroid pill in the morning, drops later in the day.
Can You Take It With Antidepressants?
Two ingredients are worth mentioning to your prescriber:
- L-tryptophan is a building block of serotonin. A review in the Journal of Psychiatry & Neuroscience says that when tryptophan is combined with MAO inhibitors, an older class of antidepressant, the risk of serotonin syndrome “is small, but it can occur”. Here it is ingredient 21 of 22, so it sits near the bottom of a 200 mg blend.
- Panax ginseng may cause manic-like symptoms with MAO inhibitors too.
Guarana and green tea also add undeclared caffeine. Mention it if you take a stimulant.
Which Ingredient Touches Which Medication?
| If you take | Ingredients to mention | What the sources warn |
|---|---|---|
| Insulin, sulfonylureas, metformin | Gymnema, Panax ginseng, chromium | Blood sugar can drop too low |
| Diuretics (water pills) | Licorice compound | Low potassium |
| Blood pressure drugs | Licorice compound, forskolin, L-arginine | Blood pressure pushed up or further down |
| Digoxin, amiodarone | Licorice compound, Eleuthero, grapefruit, guarana | Digoxin levels or toxicity up; amiodarone levels up (grapefruit) or down (guarana, animal study) |
| Warfarin, antiplatelets | Guarana, forskolin, ginseng | Bleeding risk, changed drug effect |
| Statins | Grapefruit, green tea | Changed drug levels |
| Levothyroxine | Chromium | Less absorbed, space the doses |
| MAO inhibitors, other antidepressants | L-tryptophan, ginseng | Serotonin syndrome (rare), manic-like symptoms |
How Do You Check This With Your Pharmacist In 5 Minutes?
- Take a photo of the label, or open the full ingredient list on your phone.
- Bring your medication list, supplements included.
- Ask one direct question: “Is anything on this label a problem with what I take?”
- If you get the green light, start with one dropper instead of two. The label allows either.
- Watch your numbers for two weeks: blood sugar or blood pressure, whichever your medication treats.
Cleared it with your pharmacist?
The official checkout offers 2, 3 and 6-bottle packages, with no subscription and a written 60-day money-back guarantee.
Should Taking Medication Stop You From Trying Sugar Reset?
Not by itself. It means one extra step before you order, and for diabetes and heart rhythm medication the decision belongs to your doctor. If you want to know what the formula can realistically do before you ask, read Does Sugar Reset Actually Work? and the full buyer’s guide.
This article is general information, not medical advice. It does not list every possible interaction. Always check with a doctor or pharmacist who knows your full medical history.
Frequently Asked Questions
Can I take Sugar Reset with metformin?
Metformin alone rarely causes low blood sugar, so the risk is lower than with insulin or sulfonylureas. Gymnema, Asian ginseng and chromium can all lower glucose, so check with your doctor and watch your readings for two weeks.
Can I take Sugar Reset with insulin?
Only with your doctor involved. Memorial Sloan Kettering lists additive blood sugar lowering for both chromium and Asian ginseng with insulin and sulfonylureas, and the German Federal Institute for Risk Assessment reports low blood sugar episodes when gymnema was combined with diabetes drugs.
Does Sugar Reset raise blood pressure?
It could, in theory, in sensitive people. The blend contains monoammonium glycyrrhizinate, a licorice compound linked to higher blood pressure and low potassium with regular intake. The amount is not disclosed and is likely small. If you have high blood pressure, ask your pharmacist before starting.
Is Sugar Reset safe with blood thinners like warfarin?
Ask first. Memorial Sloan Kettering warns that guarana and forskolin may add to bleeding risk, based mostly on laboratory studies. The amounts are small, but with warfarin small changes matter, so your prescriber should decide.
Does the grapefruit in Sugar Reset interact with statins?
We cannot say it does or does not. The FDA warns that grapefruit can raise blood levels of some statins and blood pressure drugs, but that warning covers grapefruit juice and fresh fruit, not extracts. The label lists grapefruit fruit extract with no amount, so treat it as a question for your pharmacist.
What should I do if I feel shaky, dizzy or unwell after starting?
Stop taking it and contact your doctor. Shakiness, sweating or confusion can be signs of low blood sugar, especially if you take diabetes medication. The written 60-day refund policy means stopping does not cost you the purchase.
Daniel Whitaker
I buy the products I write about, photograph the physical label, and put every package through checkout before I publish a number. I am not a doctor, a dietitian, or a medical professional, and nothing here is medical advice.
This article contains affiliate links. If you buy through them we may earn a commission at no extra cost to you. It does not change the label counts, the checkout totals or the criticisms above.